Stable maintenance of genetic information during meiosis and mitosis is dependent on accurate chromosome transmission. The centromere is a key component of the segregational machinery that couples chromosomes with the spindle apparatus. Most of what is known about the structure and function of the centromeres has been derived from studies on yeast cells. In Saccharomyces cerevisiae, the centromere DNA requirements for mitotic centromere function have been defined and some of the proteins required for an active complex have been identified. Centromere (...) DNA and the centromere proteins form a complex that has been studied extensively at the chromatin level. Finally, recent findings suggest that assembly and activation of the centromere are integrated in tethe cell cycle. (shrink)

Recent studies indicate a role of the sympathetic nervous system in acute and chronic pain. However, the terminology of the clinical sympathetically maintained pain (SMP) syndromes continues to be confusing and the criteria for diagnosis of SMP are being refined. (blumberg et al.) Despite significant progress in recent years, the mechanisms of the interaction between the sympathetic and sensory systems in SMP remain puzzling.

Social exclusion influences how expressions are perceived and the tendency of the perceiver to mimic them. However, less is known about social exclusion’s effect on one’s own facial expressions. The aim of the present study was to identify the effects of social exclusion on Duchenne smiling behaviour, defined as activity of both zygomaticus major and the orbicularis oculi muscles. Utilising a within-subject’s design, participants took part in the Cyberball Task in which they were both included and excluded while facial electromyography (...) was measured. We found that during the active experience of social exclusion, participants showed greater orbicularis oculi activation when compared to the social inclusion condition. Further, we found that across both conditions, participants showed greater zygomaticus major muscle activation the longer they engaged in the Cyberball Task. Order of condition also mattered, with those who experienced social exclusion before social inclusion showing the greatest overall muscle activation. These results are consistent with an affiliative function of smiling, particularly as social exclusion engaged activation of muscles associated with a Duchenne smile. (shrink)

El artículo se propone determinar los asuntos que competen a la filosofía y a la literatura a partir de, primero, un contexto común, el de la totalidad; y segundo, dos perspectivas, a saber, la cuestión por la relación de la filosofía y la literatura con la totalidad, y la relevancia ética y moral de dicha relación. La totalidad debe ser entendida de tres formas: la de la realidad y del mundo; la de las relaciones de los hombres con el mundo (...) y su comprensión; y, la de la vida individual. Estas variaciones del concepto son elaboradas por Peter Handke y presentadas como apoyo discursivo por Ursula Wolf. (shrink)

We consider total well-founded orderings on monadic terms satisfying the replacement and full invariance properties. We show that any such ordering on monadic terms in one variable and two unary function symbols must have order typeω,ω2orωω. We show that a familiar construction gives rise to continuum many such orderings of order typeω. We construct a new family of such orderings of order typeω2, and show that there are continuum many of these. We show that there are only four such orderings (...) of order typeωω, the two familiar recursive path orderings and two closely related orderings. We consider also total well-founded orderings onNnwhich are preserved under vector addition. We show that any such ordering must have order typeωkfor some 1 ≤k≤n. We show that ifkshrink)

We consider total well-founded orderings on monadic terms satisfying the replacement and full invariance properties. We show that any such ordering on monadic terms in one variable and two unary function symbols must have order type $\omega, \omega^2$ or $\omega^\omega$. We show that a familiar construction gives rise to continuum many such orderings of order type $\omega$. We construct a new family of such orderings of order type $\omega^2$, and show that there are continuum many of these. We show that (...) there are only four such orderings of order type $\omega^\omega$, the two familiar recursive path orderings and two closely related orderings. We consider also total well-founded orderings on $\mathbf{N}^n$ which are preserved under vector addition. We show that any such ordering must have order type $\omega^k$ for some $1 \leq k \leq n$. We show that if $k < n$ there are continuum many such orderings, and if $k = n$ there are only $n$!, the $n$! lexicographic orderings. (shrink)

Este ensayo se ocupa de identificar, en primera instancia, cuáles son las preguntas y temas que corresponden a la estética; en segunda instancia, su relevancia dentro de la reflexión filosófica; y, en tercera y última instancia, si se pueden tratar tales cuestiones y temas, con los procedimientos propios de la filosofía. La intención general que se identifica está encaminada a justificar la estética como un campo importante de la investigación filosófica.

En el marco de la discusión filosófica anglosajona, que ha tendido a evitar la pregunta por la constitución del ser humano debido a su carácter metafísico, surgen dos reflexiones acerca del significado de vivir la vida y sus implicaciones. Por un lado, la de Parfit en Reasons and Persons, y por otro, la de Richard Wollheim en The Thread of Life. El objetivo de este ensayo es establecer una reflexión crítica a propósito de ambos textos, cuyos planteamientos, no superan los (...) alcances especulativos de la tradición filosófica existencial respecto de la pregunta por la vida y sus implicaciones. Pero en este texto no sólo se hace una lectura crítica de ambos ensayos sino que además se intenta mostrar tanto los límites de una reflexión meramente especulativa a la hora de afrontar la pregunta por la vida humana, que justifique su valor de verdad sin recurrir a una descripción de los fenómenos; como los de una reflexión que intente forzar los fenómenos a la luz de una teoría que se considera plausible. Este es el marco teórico desde el cual se esboza una concepción de la filosofía y de su papel como reflexión especulativa alrededor de la pregunta por la vida buena. (shrink)

Comment la conception de l’homme impliquée dans les notions et principes métaphysiques de la première et de la deuxième partie de l’Éthique peut-elle être conciliée avec le rôle que l’orientation vers le bien de l’homme joue dans la pensée éthique et politique de Spinoza? L’article suivant propose de dissoudre cette tension en attribuant à Spinoza une sorte d’existentialisme. Or, cet existentialisme n’est caractérisé ni par une réflexion sur la mortalité humaine, ni par l’invocation de la notion des possibilités humaines. En (...) revanche, l’existentialisme spinoziste fait usage d’une notion tout à fait positive de la finitude humaine, et c’est de cette dernière idée que dérive la notion d’humanité. Cette lecture existentialiste du spinozisme exige que nous renoncions à toute interprétation de la doctrine du conatus dans des termes essentialistes. Mais elle ne conteste pas que la notion de conatus soit utilisée par Spinoza pour défendre son naturalisme. Contrairement aux approches existentialistes de Jean-Paul Sartre ou Martin Heidegger, l’existentialisme spinoziste ne s’oppose pas au naturalisme. L’article énonce finalement la double thèse que (1) le rationalisme spinoziste implique l’affirmation que l’homme peut accéder aux propriétés fondamentales de l’être, à savoir l’intelligibilité et la perfection de tout étant, et que (2) cela peut être éprouvé dans des expériences humaines affectives communes. (shrink)

Arthur Prior (1914-69) is regarded as New Zealand's greatest 20th-century philosopher. Until World War II, Prior seriously considered a career as a religious journalist, especially when traveling and living on the Continent and in England with his first wife. During these years, Prior wrote widely on theology and contemporary Christianity. In his correspondence with Ursula Bethell and Hugh Teague, Prior discusses in detail his religious and theological thoughts, including his shift from formal theological study into a world of journalism (...) and philosophy. These previously unknown letters, which cover the years from 1936 to 1941, chronicle a substantial part of a fascinating period in Prior's development, both theologically and philosophically, and have been transcribed and annotated for this volume. (shrink)

Der Beitrag untersucht die Langeweile auf klinischem Terrain und als literarisches/philosophisches Sujet in Abgrenzung zu benachbarten Phänomenen wie Muße, Müßiggang und Faulheit. Da sich das Phänomen Langeweile im Bedeutungsspektrum zwischen »horror vacui« (Kant) und »Windstille der Seele« (Nietzsche) einer definitorischen Klarheit entzieht, schlägt die Autorin anhand klinischer Vignetten vor, drei Qualitäten und regulierende Funktionen der Langweile zu differenzieren: eine vernichtende, mit »Desobjektalisierung« (Green) einhergehende Langeweile, eine als Abwehr eines traumabedingten Ich-Verlusts fungierende Langeweile sowie eine Langeweile als kreativer Übergangsraum. Freuds Gedanken (...) über die Existenz von »lustvolle(n) Spannungen und unlustige(n) Entspannungen« enthalten eine triebökonomische Perspektive, die einen Blick auf sehr unterschiedliche Lust- und Unlustqualitäten der Langeweile erlaubt. (shrink)

Affiliation is both an antecedent and a consequence of emotional mimicry (i.e. imitating a counterpart’s emotional expression). Thus, interacting with a disliked partner can decrease emotional mimicry, which in turn can further decrease liking. This perpetuating circle has not been investigated in the context of mental health stigma yet. The present study tested the influence of the label “schizophrenia” on liking, interpersonal closeness, and emotional mimicry. In an online experiment (n = 201), participants recruited from the general population saw several (...) videos of actors displaying emotional expressions. Actors were described with one of four labels: “schizophrenia”, “healthy”, “diabetes”, and a negative adjective (e.g. “hot-tempered”). Emotional mimicry was measured using OpenFace 2.2. Liking and interpersonal closeness were assessed with questionnaires. Overall, compared to other labels, participants reported less liking and interpersonal closeness to the actor with the schizophrenia label. However, no effect on emotional mimicry was found. The decreased liking of the schizophrenia actors was explained by a lack of knowledge about schizophrenia and the explicit stigma of schizophrenia. Our study contributes to the literature by highlighting the need to reduce the stigma of schizophrenia. (shrink)

This article discusses N. K. Jemisin's Afrofuturist utopian short story entitled “The Ones Who Stay and Fight,” the opening story of her 2018 collection, How Long 'Til Black Future Month? As is suggested by its title, Jemisin's story is a direct reply to Ursula K. Le Guin's “The Ones Who Walk Away from Omelas,” and this article discusses the ways in which Jemisin, one of the most prominent members of a new generation of SF/Fantasy writers, pays homage to, replies (...) to, and reimagines Le Guin's 1973 story in the twenty-first century. In particular, drawing on utopian scholarship, scholars of Afrofuturism, and the work of African American studies scholar-activists, it argues that Jemisin's utopia builds a world that embodies the “revolution of value” as well as the intersectional Black feminist praxis at the foundation of contemporary activist groups such as Black Lives Matter. It also argues for the ways in which Jemisin's text confronts common criticisms of utopia as well as the limits of the utopian imagination. (shrink)

Tanto la filosofía como la literatura, en cuanto búsquedas de la verdad, de respuestas frente a un núcleo de preguntas vitales, recurren a una estructura formal que necesariamente es la expresión de una actitud frente a la vida. Se plantea que la forma literaria no puede separarse del contenido filosófico, pues es el resultado de una indagación que intenta dar respuestas a asuntos particulares sobre la vida humana, así como el contenido filosófico halla expresión en una estructura formal que transmite (...) un sentido de la vida. La forma y el contenido no pueden separarse sin fracturar la visión de la vida que ofrecen tanto el texto literario como el texto filosófico. Sin embargo ¿cómo escribir, qué formas, qué estructuras, qué lenguaje utilizar para hablar de asuntos tan particulares como el amor? ¿Hasta dónde es posible escribir filosóficamente sobre la vida y sus interrogantes particulares? ¿Cuáles han sido los aportes de la literatura en la búsqueda de visiones alternativas frente a la experiencia humana? Tal es el punto de partida en la elaboración de este ensayo que intenta, por lo demás, concederle a la literatura y a sus formas de expresión, un lugar más central en el campo de la reflexión sobre el sentido de la vida y otros interrogantes importantes acerca de los asuntos humanos. (shrink)

Skeptical theists are seeking for some reasonable solutions to the evidential problem of evil. One of the most fundamental responses of skeptical theism is that the concept of “gratuitous evil”, which cannot be a proof of the absence of God. Therefore, it is not the existence of God that skeptical theism suspects. Instead, skeptical theism contemplates whether the evil in the world really has a “gratuitous” basis. This paper focuses on Peter van Inwagen's “no-minimum claim”. No-minimum claim” stands in opposition (...) to the views that assume that God minimizes the evils that exist in the world in order to achieve justice. “No-minimum claim” acknowledges that these evils still have enormous amounts to people. Thus “no-minimum claim” suggests that the evils experienced in the world are incompatible with the “best of all possible worlds” views or the other explanations of classical theodicy. According to the “no minimum claim”, the reason why the amount of evil in the world still seems so high may be God’s deliberate calculations in effecting the distribution of these evils. In order to reach these calculations, it is not necessary for the amount of evil that God allowed to reflect on the world to be perfectly manifested at the minimum level. The purpose of this paper is to consider the skeptical theism approach within the framework of Peter van Inwagen's “no-minimum claim” and to limit his arguments to an alternative approach to skeptic theism. Our claim is that such view coincides with skeptical theism, but the “no- minimum claim” still has some ambiguities at the point of the limits of evil. From this, we can conclude that the “no minimum claim” has received many objections in the skeptical theism literature and these objections are justified at certain points. (shrink)

On one way of talking about a traditional metaethical topic, realists accept that some items appear on the list of what exists in the moral or more broadly normative domain of inquiry. They then divide over whether those items are like what science and experience suggest that all other items on the list of what exists across all domains are like – naturalistic and secular. Reductive naturalists answer this further question affirmatively. Why don’t nonnaturalists? I explore the answer that it’s (...) because normative entities are “just too different” in the sense that they are countably different things. However, I argue that this answer rests on the subtle presupposition that the normative domain doesn’t also contain uncountable entities of the sort that analytic metaphysicians call “stuff”. Taking intuitions of difference seriously points the way to a novel form of metaethical reductive naturalism. The key is to identify the stuff that matters. (shrink)

The article of N. Kulish "Improvement of legal normalization of church-state relations in Ukraine - an important condition of the implementation of freedom of conscience and religion by believers" analyzes the impact of legal normalization of issues of the religious education on modern believer.

In the past 25 years or so, the issue of ethical universalizability has figured prominently in theoretical as well as practical ethics. The term, 'universaliz ability' used in connection with ethical considerations, was apparently first introduced in the mid-1950s by R. M. Hare to refer to what he characterized as a logical thesis about certain sorts of evaluative sentences (Hare, 1955). The term has since been used to cover a broad variety of ethical considerations including those associated with the ideas (...) of impartiality, consistency, justice, equality, and reversibility as well as those raised in the familar questions: 'What if everyone did that?' and 'How would you like it if someone did that to you? But this recent effloresence of the use of the term 'universalizability' is something that has deep historical roots, and has been central in various forms to the thinking about morality of some of the greatest and most influential philosophers in the western tradition. While the term is relatively new, the ideas it is now used to express have a long history. Most of these ideas and questions have been or can be formulated into a principle to be discussed, criticized, or defended. As we discuss these ideas below this prin ciple will be stated on a separate numbered line. The concepts of justice and equality were closely linked in Greek thought. These connections between these two concepts are apparent even in two authors who were hostile to the connection, Plato and Aristotle. (shrink)

ABSTRACT The phrase “ambiguous utopia” was coined by Ursula K. Le Guin in the subtitle of her novel, The Dispossessed: An Ambiguous Utopia. That work appeared when utopian narratives had been displaced by dystopian imaginaries. This article embarks on a comparative analysis of three short stories: Ursula K. Le Guin’s “The Ones Who Walk Away from Omelas”, Angélica Gorodischer’s “Of Navigators”, and N. K. Jemisin’s “The Ones Who Stay and Fight”. Each author installs ambiguity at the center of (...) their open-ended utopian imaginaries as a way to challenge dogma, pessimism, and complacency. Le Guin interrogates the boundary between belief and knowledge to hold the threat of authoritarianism at bay. Gorodischer, a friend and contemporary of Le Guin, is considered a central figure of Argentine science fiction and fantasy. Her story imagines the discovery of a second Earth set in 1492 and highlights the need for utopianism to challenge the legacy of colonization. Finally, Jemisin’s story is a critical homage to “Omelas.” Jemisin shares the decolonial impetus of Gorodischer’s fiction, and she constructs Um-Helat on an explicitly antiracist foundation. Instead of walking away, her characters actively fight the creeping threat of intolerance while working toward that better place. (shrink)

Tres filósofos catalanes: Joaquín Xirau. Eduardo Nicol. José Ferrater Mora.--La herencia de Ortega y Gasset: José Gaos. Luis Recaséns Siches. Manuel Granell. Francisco Ayala. María Zambrano.--Dos filósofos independientes: Juan D. García Bacca. Eugenio Imaz.--Panorama general de la filosofía española en América.

Mathematical pluralism can take one of three forms: (1) every consistent mathematical theory consists of truths about its own domain of individuals and relations; (2) every mathematical theory, consistent or inconsistent, consists of truths about its own (possibly uninteresting) domain of individuals and relations; and (3) the principal philosophies of mathematics are each based upon an insight or truth about the nature of mathematics that can be validated. (1) includes the multiverse approach to set theory. (2) helps us to understand (...) the significance of the distinguished non‐logical individual and relation terms of even inconsistent theories. (3) is a metaphilosophical form of mathematical pluralism and hasn't been discussed in the literature. In what follows, I show how the analysis of theoretical mathematics in object theory exhibits all three forms of mathematical pluralism. (shrink)

Contributed articles on Buddhist doctrines and philosophy; festschrift in honor of Narayan Hemandas Samtani, Buddhist scholar.

Paris, 1943. In a flash, a book is published that will shape post-war Europe like none other. Jean-Paul Sartre’s Being and Nothingness discloses utterly new insights about human freedom, about feelings such as shame and desire, and about death. The new edition of the renowned book of commentary on the magnum opus of French existentialism opens access to the work through the latest state of research.

Taftāzānī, Masʻūd ibn ʻUmar, 1322-1389?; criticiam and intepretation; Islamic law; early works.